苏州阿尔法生物实验器材有限公司

PeproTech产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。

产品描述/PERFORMANCE

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PeproTech产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。

Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinβ-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues).       


应用环境/ ENVIRONMENT

细胞凋亡、免疫系统、神经生物学等相关领域

产品说明/ INSTRUCTION

Cat.NO: 100-3

Source:

E.coli
Synonyms:
Neuregulin1 (NRG1-β1), Neu differentiation factor (rat), HRG, HRG1-β1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine, Receptor Inducing Activity), glial growth factor
AA Sequence:
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Calculated Molecular Weight:
7.5 kDa
Accession Number:
Q02297
Gene ID:
3084
crossreactivity:
Dog, Human, Mouse, Rat
Country Of Origin: USA
Not for human use.

产品参数/ PARAMETER

10µg
50µg
100µg
250µg
500µg
1mg
苏州阿尔法生物实验器材有限公司创立于2008年，坐落于苏州工业园区生物纳米园，深耕生命科学实验室配套领域18年，是苏州本土专业一站式生物实验仪器、耗材、科研试剂综合服务商，长期为全国高校科研院所、生物医药企业、第三方检测中心、医疗机构实验室提供全流程配套解决方案。
    公司持有梅特勒瑞宁、Eppendorf、海尔、知楚、耐思、天根等数十家国内外一线实验设备品牌官方正规授权，主营CO₂振荡培养箱、PCR仪、Rainin移液器、超低温冰箱、生物反应器、细胞培养耗材、分子检测试剂盒、细胞系与胎牛血清等千余种实验产品，全品类正品可溯源，配套标准化质检与完善售后保障体系。

     核心技术团队拥有十余年实验室实操服务经验，除仪器耗材供货外，同步提供实验室整体规划、设备计量校准、仪器维修、实验技术指导等增值服务，累计服务超1000家科研与医药客户； 

       苏州本地自建仓储基地，现货速发，苏州及周边区域可上门勘测、现场选型。如需咨询产品报价、申领实验样品、批量采购定制，欢迎拨打服务热线0512-62956104，也加18934597460 /18020269905咨询。

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